Plague Inc. Evolved - Bio-weapon
This one is a plague that grows more lethal the more time passes. Except that you can kinda slow this down to a crawl with gene compression abilities. Just get all 3 of them, and then get "deactivate modified genes" whenever lethality increases. Or you can just let it kill people, but that increases the risk of everyone closing down their borders, seaports and airports. Once you evolve everything you needed to, get the remaining "deactivate modified genes" and "nucleic acid neutralization" abilities. Then, once nearly everyone is infected, get the "unlock annihilate gene" ability. Note that it might not always increase lethality fully thanks to the "deactivate modified genes" ability which reduces lethality. You can just get some lethal symptom in this case, or you can leave it be.
This one is a plague that grows more lethal the more time passes. Except that you can kinda slow this down to a crawl with gene compression abilities. Just get all 3 of them, and then get "deactivate modified genes" whenever lethality increases. Or you can just let it kill people, but that increases the risk of everyone closing down their borders, seaports and airports. Once you evolve everything you needed to, get the remaining "deactivate modified genes" and "nucleic acid neutralization" abilities. Then, once nearly everyone is infected, get the "unlock annihilate gene" ability. Note that it might not always increase lethality fully thanks to the "deactivate modified genes" ability which reduces lethality. You can just get some lethal symptom in this case, or you can leave it be.