Nick Norwitz and Raphael talk about the lipid hypothesis, statins, keto, IBD & healthcare systems
Nick Norwitz and Raphael talk about their first time meeting on Twitter, the lipid hypothesis, statins, inflammatory bowel disorders (notably ulcerative colitis which both of them have experience with), ketogenic diets, health care and more. **CORRECTION** Nick misspoke at 28min50sec https://youtu.be/uNDY_Vc6MAY?t=1730 saying "Statins inhibit HMG-CoA reductase but this is not needed for ketogenesis" when in fact, HMG-CoA reductase is NOT needed for HEPATIC ketogenesis only. In his words, "I had another thought about statins, insulin resistance, and ketogenesis and a simultaneous one about pathways downstream HMG-CoA reductase and internally confused the issue. Embarrassing! Apologies". Raphael ends the podcast asking Nick what topic of concept he would like people to know more about. Nick is a 25 year old (!) PhD researcher from Oxford who researched ketogenic diets in the UK's National Health Service. He's now started his medical education at Harvard to become a doctor. Nick's high LDL-c case-report https://pubmed.ncbi.nlm.nih.gov/32351962/ Ben Bikman's 'insulin signaling bifurcation' in the liver paper https://pnas.org/content/107/8/3441 Chris Palmer's amazing case-report on a schizophrenic patient put on a ketogenic diet https://pubmed.ncbi.nlm.nih.gov/30962118/ Dr.Thomas Dayspring's Ezetimibe/Zetia paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402055/ Society for metabolic health practitioners https://metabolicpractitioners.org
Nick Norwitz and Raphael talk about their first time meeting on Twitter, the lipid hypothesis, statins, inflammatory bowel disorders (notably ulcerative colitis which both of them have experience with), ketogenic diets, health care and more. **CORRECTION** Nick misspoke at 28min50sec https://youtu.be/uNDY_Vc6MAY?t=1730 saying "Statins inhibit HMG-CoA reductase but this is not needed for ketogenesis" when in fact, HMG-CoA reductase is NOT needed for HEPATIC ketogenesis only. In his words, "I had another thought about statins, insulin resistance, and ketogenesis and a simultaneous one about pathways downstream HMG-CoA reductase and internally confused the issue. Embarrassing! Apologies". Raphael ends the podcast asking Nick what topic of concept he would like people to know more about. Nick is a 25 year old (!) PhD researcher from Oxford who researched ketogenic diets in the UK's National Health Service. He's now started his medical education at Harvard to become a doctor. Nick's high LDL-c case-report https://pubmed.ncbi.nlm.nih.gov/32351962/ Ben Bikman's 'insulin signaling bifurcation' in the liver paper https://pnas.org/content/107/8/3441 Chris Palmer's amazing case-report on a schizophrenic patient put on a ketogenic diet https://pubmed.ncbi.nlm.nih.gov/30962118/ Dr.Thomas Dayspring's Ezetimibe/Zetia paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402055/ Society for metabolic health practitioners https://metabolicpractitioners.org